STAT5 Tetramerization in Autoimmune-mediated Neuroinflammation

Multiple sclerosis (MS) is the most common neuroinflammatory disease among young adults. The overall goal of this proposal is to identify the signaling pathways and their effector mediators that regulate the interactions of pathogenic CD4+ T cells and antigen-presenting cells within the central nervous system that exacerbate neuroinflammation.

Targeting these pathways and mediators may become a novel strategy for the treatments of MS