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Chemotherapy’s effectiveness may vary with time of day, suggests WVU research

The blood-brain barrier keeps foreign substances from entering the brain. That’s good when it comes to toxins and germs, but it makes treating tumors in the brain trickier. By shielding the brain from things that would harm it, the blood-brain barrier also blocks the chemotherapy that would help it. William Walker—a researcher with the West Virginia University School of Medicine—is investigating whether the blood-brain barrier is more likely to admit chemotherapy drugs at different times of day.